/* ---------------------------------------------------------------- tokens */
/* Light only: this page is read next to a printed figure and a terminal, and a
   single palette keeps the figure's white background from floating. */
:root {
  --bg:        #fbfaf8;
  --panel:     #ffffff;
  --panel-2:   #f4f2ee;
  --ink:       #1b1d21;
  --ink-2:     #4d5560;
  --ink-3:     #79838f;
  --rule:      #e2ded7;
  --rule-2:    #cfc9c0;
  --accent:    #1d5f7a;
  --accent-2:  #0f4257;
  --accent-bg: #eef5f8;
  --warn-bg:   #fdf5e6;
  --warn-ink:  #7a5312;
  --warn-rule: #e6cd9a;

  --m-multiome: #3b82a6;
  --m-snmct:    #c4793f;
  --m-snm3c:    #7d62a8;
  --m-spatial:  #3e8e6e;
  --m-wgs:      #78838d;

  --t-prod: #2f8e76;
  --t-f1:   #c4574f;
  --t-f2:   #d39a3f;

  --maxw: 1120px;
  --mono: ui-monospace, SFMono-Regular, "SF Mono", Menlo, Consolas, monospace;
  --sans: -apple-system, BlinkMacSystemFont, "Segoe UI", Inter, Helvetica, Arial, sans-serif;
  --serif: "Iowan Old Style", "Palatino Linotype", Palatino, Georgia, serif;
}

/* ------------------------------------------------------------------ base */
* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 72px; }
body {
  margin: 0; background: var(--bg); color: var(--ink);
  font: 16px/1.65 var(--sans);
  -webkit-font-smoothing: antialiased;
}
img { max-width: 100%; height: auto; display: block; }
a { color: var(--accent); text-decoration-thickness: 1px; text-underline-offset: 2px; }
a:hover { color: var(--accent-2); }
.wrap { max-width: var(--maxw); margin: 0 auto; padding: 0 24px; }
h1, h2, h3 { line-height: 1.25; margin: 0; font-weight: 620; }
code, .mono { font-family: var(--mono); font-size: 0.86em; }
.muted { color: var(--ink-3); }

/* ------------------------------------------------------------------- nav */
.nav {
  position: sticky; top: 0; z-index: 50;
  background: color-mix(in srgb, var(--bg) 88%, transparent);
  backdrop-filter: saturate(180%) blur(12px);
  border-bottom: 1px solid var(--rule);
}
.nav .wrap { display: flex; align-items: center; gap: 22px; height: 56px; }
.nav .brand { font-weight: 660; font-size: 14px; letter-spacing: -0.01em; margin-right: auto; }
.nav a.navlink { color: var(--ink-2); text-decoration: none; font-size: 14px; }
.nav a.navlink:hover { color: var(--ink); }
@media (max-width: 820px) { .nav a.navlink { display: none; } }

/* ----------------------------------------------------------------- hero */
/* The masthead is centred as one block: logos, title, authors, links. */
.hero { padding: 26px 0 30px; border-bottom: 1px solid var(--rule); text-align: center; }
.logos {
  display: flex; align-items: center; justify-content: space-between;
  gap: 16px; margin-bottom: 30px;
}
.logos img { height: 46px; width: auto; }
.logos a { display: block; line-height: 0; }
@media (max-width: 560px) { .logos img { height: 34px; } }

.eyebrow {
  font-size: 12px; letter-spacing: 0.09em; text-transform: uppercase;
  color: var(--ink-3); font-weight: 600; margin-bottom: 14px;
}
.hero h1 {
  font-family: var(--serif); font-size: clamp(28px, 4.2vw, 44px);
  letter-spacing: -0.015em; font-weight: 600;
  max-width: 30ch; margin: 0 auto; text-wrap: balance;
}
.authors { margin: 22px auto 0; font-size: 15px; color: var(--ink-2); max-width: 78ch; }
.authors .cofirst { color: var(--ink); font-weight: 680; }
.authors sup { font-size: 10px; color: var(--ink-3); font-weight: 400; }
.affil {
  margin: 12px auto 0; font-size: 12.5px; color: var(--ink-3); line-height: 1.55;
  max-width: 82ch;
}
.affil summary { cursor: pointer; color: var(--ink-2); font-size: 13px; }
.affil ol { margin: 10px 0 0; padding-left: 20px; text-align: left; }

/* link row */
.links {
  display: flex; flex-wrap: wrap; gap: 9px; margin-top: 26px; justify-content: center;
}
.btn {
  display: inline-flex; align-items: center; gap: 7px;
  border: 1px solid var(--rule-2); background: var(--panel);
  color: var(--ink); text-decoration: none;
  padding: 8px 14px; border-radius: 7px; font-size: 13.5px; font-weight: 530;
  transition: border-color .12s, transform .12s;
}
.btn:hover { border-color: var(--accent); color: var(--ink); transform: translateY(-1px); }
.btn .ic { font-size: 14px; line-height: 1; }
.btn[aria-disabled="true"] {
  opacity: .5; pointer-events: none; border-style: dashed;
}
.btn[aria-disabled="true"]::after {
  content: "pending"; font-size: 10px; color: var(--ink-3);
  border: 1px solid var(--rule-2); border-radius: 4px; padding: 1px 5px; margin-left: 3px;
}
.btn.primary { background: var(--accent); border-color: var(--accent); color: #fff; }
.btn.primary:hover { background: var(--accent-2); border-color: var(--accent-2); color: #fff; }

/* ------------------------------------------------------------- sections */
section { padding: 54px 0; border-bottom: 1px solid var(--rule); }
.sec-head { margin-bottom: 26px; }
.sec-head h2 {
  font-family: var(--serif); font-size: 27px; font-weight: 600; letter-spacing: -0.01em;
}
.sec-head h3 { font-family: var(--serif); font-size: 20px; font-weight: 600; }
.sec-head p { margin: 9px 0 0; color: var(--ink-2); font-size: 15px; max-width: 72ch; }
.sec-head.sub { margin-bottom: 16px; padding-bottom: 8px; border-bottom: 1px solid var(--rule); }

.lede { font-size: 17.5px; line-height: 1.66; color: var(--ink); max-width: 68ch; }
.lede strong { font-weight: 640; }
.lede + .lede { margin-top: 16px; }

.keypoints { list-style: none; padding: 0; margin: 26px 0 0; display: grid; gap: 12px; }
.keypoints li {
  display: grid; grid-template-columns: 22px 1fr; gap: 12px;
  font-size: 15px; color: var(--ink-2); line-height: 1.55;
}
.keypoints .n {
  font-family: var(--mono); font-size: 11px; color: var(--accent);
  border: 1px solid var(--rule-2); border-radius: 4px; height: 20px;
  display: grid; place-items: center; margin-top: 2px;
}
.keypoints b { color: var(--ink); font-weight: 620; }

/* ---------------------------------------------------------------- figure */
.figcard {
  background: var(--panel); border: 1px solid var(--rule); border-radius: 12px;
  overflow: hidden; margin: 0;
}
.figcard > a { display: block; background: #fff; }
.figcard img { width: 100%; }
.figmeta { padding: 16px 20px 18px; }
.figmeta .tag {
  font-family: var(--mono); font-size: 11px; color: var(--accent);
  letter-spacing: .04em; font-weight: 600;
}
.figmeta h3 { font-size: 16.5px; margin: 6px 0 0; font-weight: 620; }
.figmeta .blurb { margin: 9px 0 0; font-size: 14.5px; color: var(--ink-2); line-height: 1.55; }
.figmeta details { margin-top: 12px; }
.figmeta summary {
  cursor: pointer; font-size: 12.5px; color: var(--ink-3);
  list-style: none; display: inline-flex; align-items: center; gap: 6px;
}
.figmeta summary::-webkit-details-marker { display: none; }
.figmeta summary::before { content: "▸"; font-size: 10px; transition: transform .15s; }
.figmeta details[open] summary::before { transform: rotate(90deg); }
.figmeta .legend {
  margin-top: 10px; font-size: 13px; color: var(--ink-2); line-height: 1.6;
  padding-left: 14px; border-left: 2px solid var(--rule);
}
.figmeta .dlline {
  margin: 14px 0 0; font-size: 12.5px; display: flex; gap: 10px; align-items: baseline;
}

/* ------------------------------------------------------------------ data */
.tiers { display: grid; gap: 0; margin-top: 6px; }
.tierhead {
  display: grid; grid-template-columns: 180px repeat(3, 1fr) 196px;
  gap: 10px; padding: 0 4px 10px; border-bottom: 1px solid var(--rule);
  font-size: 11px; letter-spacing: .07em; text-transform: uppercase;
  color: var(--ink-3); font-weight: 640;
}
.tierhead span:nth-child(n+2) { text-align: center; }
.trow {
  display: grid; grid-template-columns: 180px repeat(3, 1fr) 196px;
  gap: 10px; align-items: center; padding: 14px 4px;
  border-bottom: 1px solid var(--rule);
}
.trow .mod { display: flex; align-items: center; gap: 10px; }
.trow .swatch { width: 4px; height: 30px; border-radius: 2px; flex: none; }
.trow .mod b { font-size: 14.5px; font-weight: 620; display: block; }
.trow .mod span { font-size: 11.5px; color: var(--ink-3); }
.cell {
  text-align: center; border: 1px solid var(--rule); border-radius: 8px;
  padding: 6px 6px 7px; background: var(--panel); position: relative;
}
.cell b { font-size: 16px; font-weight: 640; display: block; font-variant-numeric: tabular-nums; }
.cell span { font-size: 11px; color: var(--ink-3); }
.cell.final { background: var(--panel-2); border-color: var(--rule-2); }
.trow .dl { text-align: right; }
.trow .dl a { font-size: 12.5px; text-decoration: none; }
.trow .dl .doi { display: block; font-family: var(--mono); font-size: 10.5px; color: var(--ink-3); margin-top: 3px; }

/* Linked tier cells — the number opens the portal file search for that tier. */
.cell .cellmain {
  display: block; text-decoration: none; color: inherit; border-radius: 5px;
  padding: 2px 0 1px;
}
.cell .cellmain:hover { background: var(--accent-bg); }
.cell .cellmain b { color: var(--ink); }
.cell .cellmain span { font-size: 10.5px; color: var(--ink-3); display: block; }
.cell .cellmain:hover b, .cell .cellmain:hover span { color: var(--accent); }
.cell .cellsub {
  display: block; font-size: 10.5px; margin-top: 3px; text-decoration: none;
  color: var(--ink-3); border-top: 1px solid var(--rule); padding-top: 4px;
}
.cell .cellsub:hover { color: var(--accent); }
.cell .cellsub.plain, .cell .cellsub.plain:hover { color: var(--ink-3); }
.trow.total .cell { background: transparent; border-style: dashed; }
.trow.total .dl a { font-size: 12px; }

.flow {
  display: flex; align-items: center; gap: 8px; flex-wrap: wrap;
  font-size: 12.5px; color: var(--ink-3); margin: 18px 0 28px;
  padding: 12px 14px; background: var(--panel-2); border-radius: 8px;
}
.flow b { color: var(--ink-2); font-weight: 620; }
.flow .arw { color: var(--rule-2); }

/* donor matrix */
.matrix { border-collapse: collapse; margin-top: 8px; font-size: 13.5px; width: 100%; }
.matrix th, .matrix td { padding: 9px 10px; border-bottom: 1px solid var(--rule); text-align: center; }
.matrix thead th { font-size: 11px; letter-spacing: .06em; text-transform: uppercase; color: var(--ink-3); font-weight: 640; }
.matrix tbody th { text-align: left; font-weight: 600; }
.matrix tbody th small { display: block; font-weight: 400; color: var(--ink-3); font-size: 11px; font-family: var(--mono); }
.matrix .yes { color: var(--t-prod); font-size: 15px; }
.matrix .no { color: var(--rule-2); }
.matrix tr.flag th, .matrix tr.flag td { background: var(--warn-bg); }
.pill {
  display: inline-block; font-size: 10.5px; padding: 1px 7px; border-radius: 10px;
  border: 1px solid var(--rule-2); color: var(--ink-3);
}
.pill.eff { color: var(--t-prod); border-color: color-mix(in srgb, var(--t-prod) 45%, transparent); }
.pill.ineff { color: var(--t-f2); border-color: color-mix(in srgb, var(--t-f2) 45%, transparent); }

.note {
  background: var(--warn-bg); border: 1px solid var(--warn-rule); color: var(--warn-ink);
  border-radius: 9px; padding: 13px 16px; font-size: 13.5px; line-height: 1.6; margin-top: 22px;
}
.note b { font-weight: 660; }

/* ================================================================ download */

/* Shared: small action buttons that copy or save something. */
.cbtn {
  font: 500 11.5px/1 var(--sans); color: var(--ink-2);
  background: var(--panel); border: 1px solid var(--rule-2); border-radius: 6px;
  padding: 5px 9px; cursor: pointer; white-space: nowrap;
}
.cbtn:hover { border-color: var(--accent); color: var(--accent); }
.cbtn.ok { border-color: var(--t-prod); color: var(--t-prod); }
.dbtn {
  display: inline-block; font: 560 11.5px/1 var(--sans); text-decoration: none;
  color: #fff; background: var(--accent); border: 1px solid var(--accent);
  border-radius: 6px; padding: 6px 10px; white-space: nowrap;
}
.dbtn:hover { background: var(--accent-2); border-color: var(--accent-2); color: #fff; }

/* one modality's downloads */
.dcard {
  background: var(--panel); border: 1px solid var(--rule); border-radius: 11px;
  margin-bottom: 14px; overflow: hidden;
}
.dhead {
  display: flex; align-items: center; gap: 11px;
  padding: 13px 16px; border-bottom: 1px solid var(--rule); background: var(--panel-2);
}
.dhead .swatch, .dcard > summary .swatch {
  width: 4px; height: 26px; border-radius: 2px; flex: none;
}
.dtitle { margin-right: auto; }
.dtitle b { font-size: 15px; font-weight: 640; display: block; }
.dtitle span { font-size: 12px; color: var(--ink-3); }
.accbtn {
  font-family: var(--mono); font-size: 11.5px; text-decoration: none;
  border: 1px solid var(--rule-2); border-radius: 6px; padding: 4px 8px;
}
.dcard.collapsible > summary {
  cursor: pointer; padding: 13px 16px; list-style: none;
  display: flex; align-items: center; gap: 11px; font-size: 14.5px;
}
.dcard.collapsible > summary::-webkit-details-marker { display: none; }
.dcard.collapsible > summary::after {
  content: "▸"; font-size: 10px; color: var(--ink-3); margin-left: auto;
  transition: transform .15s;
}
.dcard.collapsible[open] > summary::after { transform: rotate(90deg); }
.dcard.collapsible[open] > summary { border-bottom: 1px solid var(--rule); background: var(--panel-2); }
.dcard.collapsible > summary .muted { font-size: 12px; }
.dbody { padding: 4px 16px 18px; }

.dfoot {
  display: flex; align-items: center; gap: 9px; flex-wrap: wrap;
  padding: 11px 16px; border-top: 1px solid var(--rule); background: var(--panel-2);
  font-size: 12px;
}
.dfoot .lbl { color: var(--ink-3); }
.dfoot a { font-size: 12px; text-decoration: none; }

.about { border-top: 1px solid var(--rule); }
.about > summary {
  cursor: pointer; padding: 10px 16px; font-size: 12.5px; color: var(--ink-3);
  list-style: none;
}
.about > summary::-webkit-details-marker { display: none; }
.about > summary::before { content: "▸ "; font-size: 10px; }
.about[open] > summary { color: var(--ink-2); }
.about p.desc { padding: 0 16px; font-size: 13.5px; color: var(--ink-2); margin: 4px 0 12px; }
.about .kv { padding: 0 16px 14px; }

/* file tables */
.ftable { width: 100%; border-collapse: collapse; font-size: 12.5px; }
.ftable th {
  text-align: left; font-size: 10.5px; text-transform: uppercase; letter-spacing: .06em;
  color: var(--ink-3); padding: 8px 10px; border-bottom: 1px solid var(--rule);
  font-weight: 640;
}
.ftable td { padding: 9px 10px; border-bottom: 1px solid var(--rule); vertical-align: middle; }
.ftable tr:last-child td { border-bottom: none; }
.ftable.dl tbody tr:hover { background: var(--accent-bg); }
.ftable td.ct { font-weight: 560; color: var(--ink); }
.ftable td.ct small {
  display: block; font-weight: 400; color: var(--ink-3); font-size: 11px;
  font-family: var(--mono); margin-top: 2px;
}
.ftable td.sz, .ftable th:nth-child(3), .ftable th:nth-child(4) {
  font-variant-numeric: tabular-nums;
}
.ftable td.sz { color: var(--ink-2); white-space: nowrap; }
.ftable td.acc, .ftable td.acc a { font-family: var(--mono); font-size: 11.5px; }
.ftable td.acc a { text-decoration: none; }
.ftable td.act { text-align: right; white-space: nowrap; }
.ftable td.act > * + * { margin-left: 6px; }
.ftable td.act a:not(.dbtn) { font-size: 11.5px; text-decoration: none; }
.fmt {
  font-family: var(--mono); font-size: 10.5px; color: var(--ink-2);
  background: var(--panel-2); border: 1px solid var(--rule);
  border-radius: 4px; padding: 2px 6px; white-space: nowrap;
}
.kv { display: flex; flex-wrap: wrap; gap: 8px 20px; font-size: 12.5px; color: var(--ink-3); margin-top: 14px; }
.kv b { color: var(--ink-2); font-weight: 600; }

/* processed / raw tier blocks */
.tierblock { margin-top: 18px; }
.tbhead {
  display: flex; align-items: baseline; gap: 10px; flex-wrap: wrap;
  padding-bottom: 7px; border-bottom: 1px solid var(--rule-2); margin-top: 16px;
}
.tbhead b { font-size: 12px; letter-spacing: .06em; text-transform: uppercase; color: var(--ink-2); }
.tbhead > span { font-size: 12px; color: var(--ink-3); margin-right: auto; }
.tbhead a { font-size: 12px; text-decoration: none; }

/* the libraries behind the processed tier */
.libs { margin-top: 22px; }
.libgrid {
  display: grid; grid-template-columns: repeat(auto-fill, minmax(215px, 1fr));
  gap: 8px; margin-top: 12px;
}
.lib {
  border: 1px solid var(--rule); border-radius: 8px; padding: 9px 11px;
  text-decoration: none; color: inherit; background: var(--panel);
}
.lib:hover { border-color: var(--accent); background: var(--accent-bg); }
.lib b { display: block; font-size: 12.5px; font-weight: 600; }
.lib span { display: block; font-size: 11px; color: var(--ink-3); }
.lib .acc { font-family: var(--mono); font-size: 10.5px; margin-top: 2px; }

/* code blocks */
.code {
  border: 1px solid var(--rule); border-radius: 9px; overflow: hidden;
  background: var(--panel); margin-top: 12px;
}
.codebar {
  display: flex; align-items: center; gap: 10px; padding: 6px 8px 6px 12px;
  background: var(--panel-2); border-bottom: 1px solid var(--rule);
  font-size: 11px; color: var(--ink-3);
}
.codebar span { margin-right: auto; }
.code pre {
  margin: 0; padding: 12px; overflow-x: auto;
  font-family: var(--mono); font-size: 12px; line-height: 1.6; color: var(--ink);
}

/* the builder */
.builder {
  border: 1px solid var(--rule); border-radius: 11px; background: var(--panel);
  overflow: hidden;
}
.brow {
  display: grid; grid-template-columns: 92px 1fr; gap: 12px;
  padding: 12px 16px; border-bottom: 1px solid var(--rule); align-items: start;
}
.blbl {
  font-size: 11px; letter-spacing: .06em; text-transform: uppercase;
  color: var(--ink-3); font-weight: 640; padding-top: 7px;
}
.chips { display: flex; flex-wrap: wrap; gap: 7px; }
.chip {
  font: 540 12.5px/1.25 var(--sans); color: var(--ink-2); text-align: left;
  background: var(--panel); border: 1px solid var(--rule-2); border-radius: 7px;
  padding: 6px 10px; cursor: pointer;
}
.chip span {
  display: block; font-size: 10.5px; font-weight: 400; color: var(--ink-3);
  font-variant-numeric: tabular-nums; margin-top: 2px;
}
.chip:hover { border-color: var(--accent); color: var(--accent); }
.chip.on {
  background: var(--accent); border-color: var(--accent); color: #fff;
}
.chip.on span { color: color-mix(in srgb, #fff 78%, var(--accent)); }

.bout { padding: 14px 16px 16px; background: var(--panel-2); }
.bsum { display: flex; align-items: baseline; gap: 12px; flex-wrap: wrap; }
.bsum b { font-size: 17px; font-weight: 640; font-variant-numeric: tabular-nums; }
.bsum span { font-size: 12.5px; color: var(--ink-3); }
.bacts { display: flex; flex-wrap: wrap; gap: 8px; margin-top: 12px; }
.bnote {
  margin-top: 12px; background: var(--warn-bg); border: 1px solid var(--warn-rule);
  color: var(--warn-ink); border-radius: 8px; padding: 10px 13px; font-size: 12.5px;
  line-height: 1.55;
}
.bfiles { margin-top: 12px; }
.bfiles > summary {
  cursor: pointer; font-size: 12.5px; color: var(--ink-3); list-style: none;
}
.bfiles > summary::-webkit-details-marker { display: none; }
.bfiles > summary::before { content: "▸ "; font-size: 10px; }
.bfiles .ftable { background: var(--panel); margin-top: 10px; }
.bfiles .scroller > .ftable { min-width: 680px; }

/* recipes */
.recipes { display: grid; grid-template-columns: repeat(auto-fit, minmax(420px, 1fr)); gap: 18px; }
.recipe {
  border: 1px solid var(--rule); border-radius: 11px; background: var(--panel);
  padding: 15px 17px 17px;
}
.recipe h4 { margin: 0; font-size: 14.5px; font-weight: 620; }
.recipe p { margin: 7px 0 0; font-size: 13px; color: var(--ink-2); line-height: 1.55; }
.recipe .code { margin-top: 11px; }

footer { padding: 40px 0 64px; font-size: 13px; color: var(--ink-3); }
footer .wrap > div + div { margin-top: 8px; }
footer a { color: var(--ink-2); }

/* Wide content scrolls inside its own box so the page body never does. */
.scroller { overflow-x: auto; -webkit-overflow-scrolling: touch; }
.scroller > .matrix { min-width: 560px; }
.scroller > .tiers { min-width: 760px; }

@media (max-width: 860px) {
  .tierhead, .trow { grid-template-columns: 160px repeat(3, 1fr) 180px; }
  .brow { grid-template-columns: 1fr; gap: 7px; }
  .blbl { padding-top: 0; }
  .recipes { grid-template-columns: 1fr; }
  .dfoot, .tbhead { font-size: 11.5px; }
}